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Serologically documented loracarbef (Lorabid)-induced immune thrombocytopenia
O S Aljitawi1, K Krishnan, B R Curtis
1Division of Hematology/Oncology and Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Building 1, Dogwood Avenue, Johnson City, TN 37614, USA.
American Journal of Hematology
|April 18, 2003
Abstract:
We report here the first case of severe immune thrombocytopenia induced by a second-generation cephalosporin antibiotic, Loracarbef. A 56-year old white female developed acute severe thrombocytopenia associated with acute respiratory symptoms following administration of Loracarbef. She responded to Loracarbef withdrawal and systemic corticosteroid administration. Loracarbef-dependent platelet-reactive antibodies were demonstrable in her serum by flow cytometry.