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Updated: Aug 14, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Chemoprevention of colorectal cancer: slow, steady progress
Carol A Burke1, William M Bauer, Bret Lashner
1Department of Gastroenterology, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA. burkec1@ccf.org
Abstract:
In population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, and folate. In placebo-controlled trials in patients with familial adenomatous polyposis and in patients with sporadic colon adenomas, nonsteroidal anti-inflammatory drugs reduced the rates of adenomas, and there is a biologic rationale that they would be effective in reducing colorectal cancer as well. Randomized trials of chemopreventive agents are underway in the general population.
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