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Diarrhea associated with lansoprazole.

Sandeep Mukherjee¹

¹Section of Gastroenterology, State University of New York Health Science at Syracuse and Veterans Affairs Medical Center, Syracuse, New York, USA. smukherjee@surgery.unmc.edu

Journal of Gastroenterology and Hepatology

|April 19, 2003

Summary

Proton pump inhibitors like lansoprazole can cause diarrhea. This case study highlights an unusual instance of microscopic colitis linked to lansoprazole use, emphasizing the need for awareness.

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Area of Science:

Gastroenterology
Pharmacology

Background:

Lansoprazole is a common proton pump inhibitor for acid-related disorders.
Known side effects include diarrhea, headache, and abdominal pain in ~3% of patients.

Observation:

A previously healthy patient developed new-onset diarrhea after starting lansoprazole.
The diarrhea was attributed to microscopic colitis.

Findings:

This case presents an unusual adverse reaction to lansoprazole.
Microscopic colitis is a potential, though rare, side effect of proton pump inhibitors.

Implications:

Clinicians should consider lansoprazole as a potential cause of unexplained diarrhea.
Further investigation into the mechanisms of PPI-induced diarrhea is warranted.

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