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Lichen planus and hepatitis C virus infection
R Gimenez-García1, J L Pérez-Castrillón
1Dermatology Section, Internal Medicine Service, Hospital del Rio Hortega, Valladolid, Spain. rosagim@hotmail.com
Summary
Hepatitis C virus (HCV) antibodies were found in 8.9% of lichen planus (LP) patients, significantly higher than controls. Erosive LP showed a strong association with HCV infection, warranting liver disease screening.
Area of Science:
- Hepatology
- Dermatology
- Virology
Background:
- The link between lichen planus (LP) and liver disease is recognized, but hepatitis C virus (HCV) antibody prevalence in LP patients varies.
- Hepatitis C virus (HCV) is a significant cause of liver disease.
Purpose of the Study:
- To determine the prevalence of HCV antibodies in patients diagnosed with lichen planus (LP).
- To analyze the clinical features of LP patients who also have HCV infection.
Main Methods:
- A study involving 101 patients with cutaneous and/or mucosal LP and 99 age- and sex-matched controls.
- Data collection occurred between January 1992 and December 2000.
Main Results:
- Anti-HCV antibodies were detected in 8.9% of LP patients versus 2.02% of controls.
- An odds ratio of 4.74 indicated a significantly higher likelihood of HCV positivity in LP patients.
- A statistically significant association was found specifically between erosive LP and HCV infection.
Conclusions:
- Patients with lichen planus (LP), particularly the erosive form, should be evaluated for potential liver disease caused by HCV.
- Early screening for HCV-related liver disease is recommended for LP patients.