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Aquagenic keratoderma.

I Betlloch1, G Vergara, M P Albares

  • 1Department of Dermatology, General University Hospital, Alicante, Spain. betlloch_isa@gva.es

Journal of the European Academy of Dermatology and Venereology : JEADV
|April 19, 2003
PubMed
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Aquagenic keratoderma causes temporary hand lesions in young females after water exposure. This case suggests a horny layer alteration, not eccrine duct issues, as the cause in adolescents.

Area of Science:

  • Dermatology
  • Histopathology
  • Adolescent Medicine

Background:

  • Aquagenic keratoderma is a transient condition affecting young females, presenting as palmar lesions after water immersion.
  • Previous reports suggest hyperkeratosis and dilated eccrine ducts, with potential pathogenic mechanisms involving eccrine duct aberrations.

Observation:

  • A new case of aquagenic keratoderma in a female adolescent is presented.
  • The epidermis appeared normal microscopically.
  • Clinical changes were noted, particularly after water immersion.

Findings:

  • Histological examination revealed hyperkeratosis and dilated eccrine ducts in prior cases.
  • This case showed a normal epidermal appearance, challenging previous histological findings.
  • The clinical presentation was attributed to a structural alteration of the horny layer.

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Implications:

  • The findings suggest that aquagenic keratoderma in adolescents may stem from horny layer structural changes rather than eccrine duct abnormalities.
  • This challenges the previously proposed pathogenic mechanism.
  • Further research into the adolescent stratum corneum's role in aquagenic keratoderma is warranted.