Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kidney stone matrix. Differences in acidic protein composition.

A R Spector, A Gray, E L Prien

    Investigative Urology
    |May 11, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Drug management of TB in the intensive care setting: an international multicentre study.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
    Same author

    Prevalence of transthyretin cardiac amyloidosis in undifferentiated heart failure with preserved ejection fraction.

    ESC heart failure·2024
    Same author

    Patient evaluation of Klick, a technology-enabled, nurse-delivered HIV outpatient pathway.

    HIV medicine·2024
    Same author

    The societal economic impact of vision impairment in adults 40 years and above: findings from the National Eye Survey of Trinidad and Tobago.

    Eye (London, England)·2023
    Same author

    Urgent appeal to allow all professional nurses and midwives to prescribe pre-exposure prophylaxis (PrEP) in South Africa.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023
    Same author

    Proactive care post-discharge to reduce 30 day readmissions to hospital.

    The International journal of risk & safety in medicine·2022
    Same journal

    Post ischemic renal bleeding from fenal puncture site.

    Investigative urology·1981
    Same journal

    Vasoactive intestinal polypeptide (VIP) in the male genitourinary tract: concentration and motor effect.

    Investigative urology·1981
    Same journal

    Enzymatic changes in experimental testicular torsion.

    Investigative urology·1981
    Same journal

    Effects of DES on the morphology of the lobes of the baboon prostate.

    Investigative urology·1981
    Same journal

    Nucleation kinetics in the calcium oxalate-sodium urate monohydrate system.

    Investigative urology·1981
    Same journal

    Plasma lipid bound sialic acid in patients with prostate and bladder cancer.

    Investigative urology·1981
    See all related articles

    Kidney stone organic matrices are rich in acidic amino acids, with specific compositions varying by mineral type. This suggests the organic matrix may act as a nucleating agent in stone formation.

    Area of Science:

    • Biochemistry
    • Urology
    • Materials Science

    Background:

    • Kidney stones are complex structures with organic and inorganic components.
    • The role of organic matrices in kidney stone formation is not fully understood.

    Purpose of the Study:

    • To analyze the amino acid composition of organic matrices from different types of kidney stones.
    • To investigate the potential role of the organic matrix as a nucleating agent.

    Main Methods:

    • Isolation of organic matrices from kidney stones of varying mineral compositions (calcium oxalate, uric acid, apatite-struvite).
    • Analysis of the amino acid composition of the isolated organic matrices.

    Main Results:

    • Organic matrices were found to be abundant in acidic amino acids (aspartic and glutamic acid).

    Related Experiment Videos

  • Calcium oxalate stones showed 50% acidic amino acid residues; uric acid stones showed over 65%.
  • Apatite-struvite stones contained 30% acidic amino acids and 20% glycine.

    • Conclusions:

    • The specific amino acid composition of the organic matrix differs based on the stone's mineral content.
    • These findings suggest that the organic matrix may function as a nucleating agent in kidney stone formation.