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Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein
Eric A Gaucher1, Michael M Miyamoto, Steven A Benner
1NASA Astrobiology Institute and Foundation for Applied Molecular Evolution, University of Florida, Gainesville, Florida, 32611-7200, USA. gaucher@ufl.edu
Genetics
|April 19, 2003
Abstract:
The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.