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Updated: Jul 18, 2026

Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Rakez Kayed1, Elizabeth Head, Jennifer L Thompson
1Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.
Abstract:
Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Abeta peptide in Alzheimer's disease (AD). Here we show that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomers regardless of sequence. The in vitro toxicity of soluble oligomers is inhibited by oligomer-specific antibody. Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity.
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