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Updated: Sep 26, 2026
Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
Published on: November 14, 2013
Body and brain development following exposure to 60Co gamma-irradiation during pregnancy in mice
X Z Sun1, M Inouye, S Hayasaka
1Department of Teratology and Genetics, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Abstract:
We studied the dose-response effects of gamma-irradiation on the weight gains of the body and the brain in ICR mice exposed to various doses of 60Co gamma-irradiation ranging from 0 to 1.5 Gy on day 13 of pregnancy (El3). We found that 0.5 Gy gamma-irradiation caused a significant reduction in brain weight but not in body weight among 6-week-old mice. Higher doses (1.0, 1.5 Gy) seriously inhibited body and brain development, resulting in significantly low weights at 6 weeks of age. A significantly lower brain weight among fetuses exposed to 1.5 Gy was found as early as 24 hours after exposure, while significant reductions in the body weight of these same fetuses appeared 3 days after exposure. The effects of radiation on brain and body development were similar for both males and females.
