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The Entner-Doudoroff pathway has little effect on Helicobacter pylori colonization of mice
Amy E Wanken1, Tyrrell Conway, Kathryn A Eaton
1Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA.
Infection and Immunity
|April 22, 2003
Abstract:
Helicobacter pylori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed. Colonization densities were lower and minimum infectious doses were higher for mutant strains than for wild-type strains. In spite of better colonization, however, wild-type strains did not displace the mutant in cocolonization experiments. Loss of 6PGD diminishes the fitness of H. pylori in vivo, but the pathway is nonessential for colonization.