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Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania

Hervé Pascalis1, Anne Lavergne, Eliane Bourreau

  • 1Immunologie des Leishmanioses, Institut Pasteur de le Guyane Française, Institut d'Etudes Supérieures de la Guyane, Université Antilles-Guyane, Cayenne, French Guiana.

Infection and Immunity
|April 22, 2003
PubMed

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...