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Related Experiment Videos

Cyclopia.

Fahri Yilmaz1, Nihal Kilinc

  • 1Department of Pathology, Dicle Universitesi, Diyarbakir, Turkey. fyilmaz@dicle.edu.tr

Saudi Medical Journal
|April 22, 2003
PubMed
Summary

True cyclopia, a rare congenital anomaly suppressing eye development, was observed in a fetus with additional abnormalities. This case provides insights into the histogenesis mechanisms of cyclopia and associated conditions.

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Area of Science:

  • Developmental Biology
  • Medical Genetics
  • Teratology

Background:

  • Cyclopia is a severe congenital anomaly characterized by the failure of prosencephalic cleavage, resulting in a single midline eye.
  • It is a rare condition, often associated with holoprosencephaly and other significant fetal malformations.
  • Understanding the underlying mechanisms of cyclopia is crucial for diagnosis and genetic counseling.

Purpose of the Study:

  • To report a rare case of true cyclopia in a fetus.
  • To document associated anomalies in the affected fetus.
  • To discuss the potential histogenetic mechanisms and review existing literature on cyclopia.

Main Methods:

  • Case report of a fetus diagnosed with cyclopia.
  • Detailed pathological examination and documentation of all observed anomalies.
  • Literature review on cyclopia and related developmental disorders.

Main Results:

  • The fetus presented with true cyclopia, indicating suppressed development of two separate eyes.
  • Additional congenital anomalies were identified in conjunction with cyclopia.
  • The study provides a detailed account of the histogenesis in this specific case.

Conclusions:

  • This case highlights the complex presentation of cyclopia with multiple anomalies.
  • The findings contribute to the understanding of the histogenesis of cyclopia.
  • Further research into the genetic and environmental factors influencing cyclopia is warranted.

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