Innovative therapies in wound healing
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Updated: Sep 26, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
Published on: December 27, 2024
1Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA.
Background:
Apligraf is a bioengineered skin product composed of neonatal fibroblasts and keratinocytes. The FDA has approved Apligraf for the treatment of chronic venous ulcers and diabetic ulcers.
Objective:
We review the development of bioengineered skin, examine the cellular activities of various growth factors that may facilitate wound healing, and discuss the results of clinical trials with a particular construct, Apligraf, as proof of principle.
Conclusion:
Bioengineered skin acts as a "smart" delivery system for growth factors and other stimulatory substances. Not only does it present a novel treatment for chronic and diabetic ulcers, but it could also be considered for application to other types of acute wounds.
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