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Fast rolitetracycline stability determination by spectrophotometer variable-temperature kinetic experiments
G Alibrandi1, S Coppolino, N Micali
1Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Messina, Italy.
Bollettino Chimico Farmaceutico
|April 23, 2003
Abstract:
The pseudo-first order rate constant for the hydrolysis of rolitetracycline as a function of temperature was obtained by performing variable-temperature kinetic experiments. The results are in agreement with those obtained at constant-parameter kinetics but saving experimental time and chemicals.