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Quantitative EEG abnormalities in recently abstinent methamphetamine dependent individuals.

Thomas F Newton1, Ian A Cook, Ari D Kalechstein

  • 1Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA. tnewton@ucla.edu

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|April 23, 2003
PubMed
Summary

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Quantitative electroencephalography (EEG) revealed brain abnormalities in recently abstinent methamphetamine dependent individuals. These findings suggest generalized encephalopathy, potentially linked to cognitive and psychiatric issues.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Medicine

Background:

  • Methamphetamine exposure can cause lasting dopaminergic neuron damage in preclinical models and likely in humans.
  • Quantitative electroencephalography (QEEG) has identified brain function abnormalities in cocaine dependence but not yet in methamphetamine dependence.

Purpose of the Study:

  • To investigate brain electrical activity abnormalities in methamphetamine-dependent individuals using QEEG.
  • To compare QEEG findings between methamphetamine-dependent subjects and non-drug-using controls.

Main Methods:

  • 11 methamphetamine-dependent subjects (4 days abstinence) and 11 controls underwent resting-state EEG.
  • Absolute EEG power in delta, theta, alpha, and beta bands was quantified using fast Fourier transform.

Related Experiment Videos

  • Conventional EEG tracings were interpreted by a blinded electroencephalographer.

    • Main Results:

    • Methamphetamine-dependent subjects showed increased delta and theta band EEG power compared to controls.
    • Alpha and beta band power did not differ between groups.
    • 64% of methamphetamine-dependent subjects had abnormal conventional EEGs, versus 18% in controls.

    Conclusions:

    • Recently abstinent methamphetamine-dependent individuals exhibit QEEG abnormalities indicative of generalized encephalopathy.
    • These encephalopathic changes may correlate with cognitive and psychiatric deficits, warranting further research.