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Event-related slow-wave activity in two subtypes of attention-deficit/hyperactivity disorder
Stuart J Johnstone1, Robert J Barry, Aneta Dimoska
1Brain & Behaviour Research Institute, University of Wollongong, Wollongong 2522, Australia. sjohnsto@uow.edu.au
Objective:
Previous time-frequency studies have indicated that event-related low-frequency activity has important effects on component topography and developmental effects in auditory event-related potentials (ERPs) of children and adolescents. This study investigated the influence of event-related slow-wave (SW) (0.01-2 Hz) activity in the group differences seen between children with and without attention-deficit/hyperactivity disorder (AD/HD) of different subtypes.
Methods:
Time-frequency analysis techniques were applied to auditory ERP data derived from children with AD/HD predominantly inattentive type (n = 30), AD/HD combined type (n = 30) and age-matched control subjects (n = 30).
Results:
Event-related early frontal negative and late posterior positive SW components were reduced in the AD/HD combined type group, but not AD/HD inattentive type group, relative to controls. The RESIDUAL ERPs, which represented event-related 2-12 Hz activity, showed clinical vs. control group differences in components that were similar in both AD/HD subtype groups.
Conclusions:
The time-frequency results showed that event-related SW (0.1-2 Hz) activity contributes importantly to group differences between AD/HD and control children, and the pattern of group differences from controls for each of the AD/HD subtype groups, which are evident in raw ERPs. These results emphasise both the clinical and developmental importance of this form of analysis.
Significance:
This novel approach revealed additional specific information about stimulus processing and regional inhibition/activation in two AD/HD subtypes, relative to control subjects.