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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

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Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
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Perforating calcific elastosis.

L Caldas Lopes1, L Lobo, R Bajanca

  • 1Serviço de Dermatologia, Hospital do Desterro, Rua Nova do Desterro, 1169-100 Lisbon, Portugal. luisa.c.lopes@clix.pt

Journal of the European Academy of Dermatology and Venereology : JEADV
|April 23, 2003
PubMed
Summary
This summary is machine-generated.

Perforating calcific elastosis (PCE) is a rare skin condition presenting with yellowish patches and papules. Diagnosis relies on distinguishing it from pseudoxanthoma elasticum (PXE) through patient history.

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Area of Science:

  • Dermatology
  • Histopathology
  • Medical Diagnosis

Background:

  • Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting elastic tissue.
  • Distinguishing PXE from similar dermatoses is crucial for accurate diagnosis and management.

Observation:

  • A 69-year-old woman presented with abdominal skin findings: a reticulated yellowish patch and scattered keratotic papules.
  • Histopathological analysis revealed changes resembling PXE.

Findings:

  • The patient lacked personal or familial history of PXE, leading to a diagnosis of perforating calcific elastosis (PCE).
  • PCE is characterized as a localized, acquired dermatosis.
  • PCE is recognized as a distinct clinical entity separate from PXE.

Implications:

  • This case highlights the importance of clinical history in differentiating PCE from PXE.
  • Accurate diagnosis of PCE is essential for understanding its localized nature and acquired characteristics.
  • Further research may elucidate the specific pathogenesis of PCE as a distinct condition.