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Feedback regulation of pathogen-specific T cell priming.
1Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Immunity
|April 23, 2003
Summary
The host
Area of Science:
- Immunology
- Microbial Pathogenesis
- T cell Biology
Background:
- MHC class I antigen presentation is crucial for CD8 T cell priming during infection.
- The in vivo duration of functional antigen presentation is not well understood.
Purpose of the Study:
- To investigate the temporal dynamics of T cell activation during bacterial infection.
- To define the duration of effective in vivo antigen presentation.
Main Methods:
- Characterization of naive and memory T cell activation at various time points during bacterial infection.
- Assessment of T cell priming duration in vivo.
Main Results:
- Effective T cell priming by antigen presentation is significantly shorter than the duration of bacterial infection.
- The duration of antigen presentation inversely correlates with the development of pathogen-specific cytolytic T lymphocytes.
- A feedback mechanism limits the duration of in vivo antigen presentation.
Conclusions:
- Host antigen presentation has a limited duration during infection.
- This temporal restriction modulates T cell responses by limiting naive T cell recruitment.
- A feedback loop regulates the duration of adaptive immune responses.