The synaptic cluster (glomerulus) in the inferior olivary nucleus

This report describes the fine structural features and distribution of the synaptic cluster (glomerulus) within the inferior olivary nucleus of the opossum. The postsynaptic elements typically include spiny appendages and small diameter dendrites which exhibit attachment plaques and gap junctions. Profiles presynaptic to the central core of postsynaptic elements were differentiated on the basis of vesicle shape, vesicle size, as measured by a computer system, and junctional characteristics. Three categories of terminals with clear vesicles are present within the synaptic clusters in all nuclear divisions of the olive, whereas a fourth with large dense core vesicles is restricted primarily to the principal nucleus. The groups of pre and postsynaptic elements are surrounded by astrocytic lamellae and are most frequently encountered in the principal and rostral portions of the medial accessory nuclei. Possible identification of the sources of the synaptic components is discussed in relation to data available from Golgi impregnations, physiological reports and hodological evidence.