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TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus
Georg Lautscham1, Alan Rickinson, Neil Blake
1Max Delbrueck Centrum for Molecular Medicine, 13125 Berlin, Germany.
Microbes and Infection
|April 23, 2003
Abstract:
For recognition by CD8(+) lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number.