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Aberrant processing of Fas transcripts in adult T-cell leukemia: a possible role in tumor cell survival
Masayuki Tawara1, Takahiro Maeda, Yasuaki Yamada
1Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Abstract:
In adult T-cell leukemia (ATL), tumor cells commonly express abundant membrane-bound Fas antigen. We reported a significant correlation between Fas expression status of ATL patients and their clinical outcome. In the current study, we analyzed the Fas cDNA sequence of the distinctive ATL cases that barely expressed mFas identified during the previous study. According to the results, changes in the Fas amino acid sequence were deduced in two of seven cases. Furthermore, we identified seven novel variants of Fas mRNA produced by alternative splicing. Our data indicates the diversity of Fas gene expression at a mRNA level in ATL.
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