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Acceleration and augmentation strategies for treating bipolar depression.

Lori L Altshuler1, Mark A Frye, Michael J Gitlin

  • 1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA.

Biological Psychiatry
|April 23, 2003
PubMed
Summary

Bipolar depression treatment trials are scarce. This review examines combination strategies like adjunctive, acceleration, and augmentation, highlighting limited controlled studies on the latter two for optimizing treatment response.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Bipolar depression is prevalent and causes significant morbidity.
  • Limited randomized controlled trials (RCTs) exist for bipolar depression treatments.
  • Few studies focus on optimizing treatment response in bipolar depression.

Purpose of the Study:

  • To review common combination strategies for bipolar depression.
  • To define adjunctive, acceleration, and augmentation approaches.
  • To discuss the existing controlled literature on acceleration and augmentation.

Main Methods:

  • Literature review of controlled studies.
  • Analysis of combination treatment strategies.
  • Definition of therapeutic approaches.

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Main Results:

  • Limited controlled studies are available for acceleration and augmentation strategies.
  • The literature on optimizing bipolar depression treatment response is sparse.
  • Common combination strategies include adjunctive, acceleration, and augmentation.

Conclusions:

  • More rigorous RCTs are needed to evaluate combination therapies for bipolar depression.
  • Understanding different combination strategies is crucial for treatment optimization.
  • Current evidence for acceleration and augmentation in bipolar depression is limited.