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5-HT3 receptors in the CNS: 3B or not 3B?
Johannes A van Hooft1, Jerrel L Yakel
1University of Amsterdam, Swammerdam Institute for Life Sciences, section Neurobiology, PO Box 94084, NL-1090 GB Amsterdam, The Netherlands.
Trends in Pharmacological Sciences
|April 23, 2003
Abstract:
5-HT(3) receptors are widely distributed in the CNS and PNS where they participate in a variety of physiological processes. Native 5-HT(3) receptors in the CNS display functional and pharmacological heterogeneity, suggesting the existence of multiple receptor subunits. However, recent evidence suggests that of the two known subunits only the 5-HT(3A) receptor subunit (and not the 5-HT(3B) receptor subunit) is functionally present in the CNS. The molecular makeup of the 5-HT(3) receptor therefore remains an open question.