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Extrapyramidal reactions to ondansetron: cross-reactivity between ondansetron and prochlorperazine?
Juraj Sprung1, Faisal M Choudhry, Brian A Hall
1Department of Anesthesiology, Mayo Clinic, Rochester, MN.
Anesthesia and Analgesia
|April 23, 2003
Abstract
Implications:
Ondansetron can rarely induce extrapyramidal reactions in susceptible individuals. Our patient had a history of drug-induced dystonic reaction; therefore, these patients may be susceptible to extrapyramidal adverse reactions after ondansetron.
Insights
Ondansetron rarely causes extrapyramidal reactions. Patients with a history of drug-induced dystonic reactions may be more susceptible to these adverse effects from ondansetron.
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Medicine
Background:
- Ondansetron is a widely used antiemetic medication.
- Extrapyramidal reactions are rare but serious adverse effects associated with certain medications.
Observation:
- A patient experienced an adverse reaction after ondansetron administration.
- The patient had a documented history of drug-induced dystonic reactions.
Findings:
- Ondansetron can induce extrapyramidal reactions in susceptible individuals.
- The patient's history suggests a predisposition to such reactions.
Implications:
- Patients with a history of drug-induced dystonic reactions may be at increased risk for extrapyramidal adverse reactions to ondansetron.
- Caution and monitoring are advised when prescribing ondansetron to patients with a similar history.