Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age differentiation in depression: biochemical aspects.

M A Lipton

    Journal of Gerontology
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Elderly individuals aged 55-70 experience the highest rates of depression due to biological and psychosocial factors. Effective treatment involves tricyclic antidepressants and environmental support.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mechanism of the enzymatic synthesis of acetylcholine.

    Federation proceedings·2010
    Same author

    An apparatus for dispersing finely divided dusts.

    The Journal of industrial hygiene and toxicology·2010
    Same author

    Effect of anesthetics and convulsants on brain acetylcholine content.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
    Same author

    Biological factors in calcification in bone.

    Transactions. Conference on Metabolic Aspects of Convalescence·2010
    Same author

    Symposium on bone metabolism.

    Transactions. Conference on Metabolic Aspects of Convalescence·2010
    Same author

    Studies on biological oxidations; the metabolism of the bone marrow.

    The Journal of biological chemistry·2010

    Area of Science:

    • Gerontology
    • Neuroscience
    • Psychiatry

    Background:

    • Depression affects all ages, but the elderly (55-70) show the highest incidence and prevalence.
    • While life stresses exacerbate depression in predisposed elderly individuals, incidence also rises in those without prior history.
    • The exact causes of depression remain multifaceted and not fully elucidated across all age groups.

    Purpose of the Study:

    • To explore the increased susceptibility to depression in the elderly population.
    • To investigate the biological and psychosocial factors contributing to late-life depression.
    • To understand the role of neurotransmitter systems and aging in geriatric depression.

    Main Methods:

    • Review of evidence on antidepressant drug mechanisms of action.

    Related Experiment Videos

  • Analysis of neurotransmitter system alterations in depression.
  • Consideration of genetic control of enzymes involved in neurotransmission.
  • Examination of age-related changes in enzyme activity.

    • Main Results:

    • Depression is linked to altered neurotransmitter synthesis, storage, release, and utilization.
    • Enzyme activity crucial for neurotransmission is genetically controlled and changes with aging.
    • The interplay between biological (enzyme activity) and psychosocial factors increases depression risk in the elderly.

    Conclusions:

    • Aging interacts with biological predispositions and psychosocial stressors to elevate depression risk in older adults.
    • Tricyclic antidepressants are generally effective for treating depression in the elderly.
    • Treatment efficacy is enhanced by integrating appropriate environmental support systems alongside pharmacotherapy.