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Updated: Jul 22, 2026
Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
Published on: January 25, 2017
Neutrophil aggregates in a 13-year-old girl: a rare hematological phenomenon
A Claviez1, H-A Horst, R Santer
1Department of Pediatrics, University of Kiel, Schwanenweg 20, 24105 Kiel, Germany. a.claviez@pediatrics.uni-kiel.de
Abstract:
Aggregation of neutrophils in peripheral blood smears is a very rare, mostly self-limiting phenomenon and may result in pseudoleukopenia. In the majority of cases, malignancies, infections, or hepatic disorders have been identified as the underlying condition. Although the exact reason for neutrophil aggregation in vitro has not been clarified, its relation to the use of ethylenediaminetetraacetate acid as an anticoagulant has been described in adults. We report here on the occurrence of transient neutrophil aggregation in a 13-year-old girl with Herpes simplex and concomitant Mycoplasma pneumoniae infection.
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