Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain tumors and polyomaviruses.

Sidney Croul1, Jessica Otte, Kamel Khalili

  • 1Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA. sidney.croul@drexel.edu

Journal of Neurovirology
|April 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward Autonomous Histotripsy: Integrating Deep Learning Segmentation With Robotic Control for Glioblastoma.

Ultrasound in medicine & biology·2026
Same author

Barriers and facilitators to reducing overuse of thyroid function testing: a mixed-methods study.

BMJ quality & safety·2025
Same author

Thyroid testing in primary hypothyroidism.

African journal of primary health care & family medicine·2025
Same author

CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9.

Molecular therapy. Nucleic acids·2025
Same author

Neurotropic Viruses as Acute and Insidious Drivers of Aging.

Biomolecules·2025
Same author

CRISPR-Cas9-mediated genome editing delivered by a single AAV9 vector inhibits HSV-1 reactivation in a latent rabbit keratitis model.

Molecular therapy. Methods & clinical development·2024
Same journal

Circadian-guided oncolytic virotherapy for glioblastoma.

Journal of neurovirology·2026
Same journal

HTLV-1 infection in patients with neurological manifestations in Northeast Brazil.

Journal of neurovirology·2026
Same journal

Hantavirus infection: Neurologic manifestations should not be overlooked.

Journal of neurovirology·2026
Same journal

Zika virus infection in the brains of lymphocyte-deficient mice does not lead to neurological symptoms despite sustained high viral load.

Journal of neurovirology·2026
Same journal

Cognitive and sensorimotor impairments in virally suppressed people with and without HIV in Uganda: Associations with neurofilament light chain as a biomarker of neuronal injury.

Journal of neurovirology·2026
Same journal

Diffuse cerebral microhemorrhages in West Nile virus neuroinvasive disease: a case report.

Journal of neurovirology·2026
See all related articles

Polyomaviruses like JC virus (JCV) and BK virus (BKV) are linked to human brain tumors. Research explores the connection between these viruses and CNS neoplasms, including ependymoma and glial tumors.

Area of Science:

  • Virology
  • Oncology
  • Neuroscience

Background:

  • Polyomaviruses, including JC virus (JCV), BK virus (BKV), and simian virus 40 (SV40), are increasingly isolated from human tumors.
  • JCV and BKV are widespread pathogens that can reactivate during immunosuppression, causing diseases like progressive multifocal leukoencephalopathy and kidney issues.
  • SV40, previously thought to affect only monkeys, has been found in various human cancers.

Purpose of the Study:

  • To review the potential involvement of polyomaviruses (JCV, BKV, SV40) in the development of human brain tumors.
  • To consolidate evidence linking polyomaviruses to central nervous system (CNS) neoplasms.

Main Methods:

  • Literature review focusing on studies reporting the isolation of polyomaviruses from human tumors.

Related Experiment Videos

  • Analysis of existing research on polyomavirus replication and associated diseases.

    • Main Results:

    • JCV DNA has been detected in various human CNS tumors, including medulloblastoma, ependymoma, and glial tumors.
    • SV40 has been isolated from human cancers such as mesothelioma, ependymoma, and non-Hodgkin's lymphoma.
    • The review highlights the growing body of evidence suggesting a role for these viruses in oncogenesis.

    Conclusions:

    • Polyomaviruses, particularly JCV and SV40, are implicated in the etiology of certain human brain tumors.
    • Further research is warranted to elucidate the mechanisms by which these viruses contribute to human cancers.