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Related Experiment Videos

The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex.

E R Podack, W P Kolb, H J Muller-Eberhard

    Journal of Immunology (Baltimore, Md. : 1950)
    |May 1, 1976
    PubMed
    Summary
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    The complement system's C5b-9 membrane attack complex has a consistent composition. Band V protein is a subunit of the soluble complex, likely representing a membrane site.

    Area of Science:

    • Immunology
    • Molecular Biology

    Background:

    • The complement system is crucial for innate immunity.
    • The membrane attack complex (MAC), C5b-9, is the terminal effector of complement.
    • Understanding MAC composition is key to its function.

    Purpose of the Study:

    • To investigate the composition of the soluble membrane attack complex (C5b-9).
    • To identify the role of Band V protein in the C5b-9 complex.

    Main Methods:

    • Biochemical analysis of the complement cascade.
    • Isolation and characterization of soluble C5b-9 complexes.

    Main Results:

    • The composition of the C5b-9 complex is invariant across different complement activation pathways.

    Related Experiment Videos

  • Band V protein was identified as a consistent subunit of the soluble C5b-9 complex.
  • Band V protein is not essential for complement-dependent cytolysis.

    • Conclusions:

    • The final structure of the membrane attack complex (C5b-9) is conserved regardless of the activation pathway.
    • Band V protein is a component of the soluble C5b-9 complex.
    • Band V protein may serve as a membrane-bound equivalent to the nascent C5b-9 complex in serum.