Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A short introduction to pharmacokinetics.

R Urso1, P Blardi, G Giorgi

  • 1Dipartimento di Farmacologia "Giorgio Segre", Universita di Siena (Italy).

European Review for Medical and Pharmacological Sciences
|April 24, 2003
PubMed
Summary

Pharmacokinetics, the study of drug absorption, distribution, biotransformation, and elimination, can be effectively summarized using mathematical models. These models, particularly compartmental models, offer deeper insights into drug kinetics and physiological processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Floating offshore wind potential for Mediterranean countries.

Heliyon·2024
Same author

Proteomic analysis of the effect of hemin in breast cancer.

Scientific reports·2023
Same author

Iron cycle disruption by heme oxygenase-1 activation leads to a reduced breast cancer cell survival.

Biochimica et biophysica acta. Molecular basis of disease·2022
Same author

Photo-induced lattice distortion in 2H-MoTe<sub>2</sub> probed by time-resolved core level photoemission.

Faraday discussions·2022
Same author

Hyaluronan derivatives bearing variable densities of ferulic acid residues.

Journal of materials chemistry. B·2020
Same author

Renin-angiotensin system at the crossroad of hypertension and hypercholesterolemia.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2016

Area of Science:

  • Pharmacokinetics
  • Mathematical Modeling
  • Drug Development

Background:

  • Pharmacokinetics investigates drug absorption, distribution, biotransformation, and elimination in humans and animals.
  • Key pharmacokinetic parameters include Cmax, Tmax, t 1/2, and AUC, which summarize drug profiles.
  • Mathematical functions can interpolate and extrapolate drug concentration data for detailed analysis.

Purpose of the Study:

  • To explore the application of mathematical functions and models in pharmacokinetic data analysis.
  • To differentiate between data simulation and model building in pharmacokinetic studies.
  • To define new pharmacokinetic parameters using models for better understanding of drug behavior.

Main Methods:

  • Utilizing multiexponential functions for interpolating and reducing pharmacokinetic data.

Related Experiment Videos

  • Employing compartmental models as reference models, as their solutions are multiexponential functions.
  • Iterative process of experimentation and simulation for pharmacokinetic model building.

    • Main Results:

    • Mathematical functions can reduce complex pharmacokinetic data into a small set of parameters.
    • Compartmental models facilitate the definition of key parameters like clearance and volume of distribution.
    • Models enable estimation of drug absorption, such as bioavailability, after extravascular administration.

    Conclusions:

    • Pharmacokinetic modeling provides a robust framework for understanding drug behavior.
    • Compartmental models enhance the interpretation of drug kinetics and their relationship to physiological processes.
    • Model building is an iterative, interactive process between experimenters and computational tools.