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Selective synthesis and reactions of 6-substituted-2-beta-galactosyl-1,2,4-triazines of potential anticancer activity

Abdel Kader Mansour¹, Mohga M Eid, Nasser S A M Khalil

¹Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. clff@intouch.com

Nucleosides, Nucleotides & Nucleic Acids

|April 24, 2003

Abstract:

Selective synthesis and reactions of different 6-substituted-2-beta-D-galactosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-ones using the developed amino or aryl protecting group strategy were investigated. Primary human anticancer screening of twelve selected compounds (in vitro) resulted in an active compound against both MCF7 (Breast) and SF-268(CNS) cell lines.

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