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Synthesis of a novel aldehyde: 4-O-methyl-5-formylmethyl-2'-deoxyuridine
Chung-Shan Yu1, Franz Oberdorfer
1Abteilung E0300-Radiochemie und Radiopharmakologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Nucleosides, Nucleotides & Nucleic Acids
|April 24, 2003
Abstract:
The synthesis of the blocked nucleoside 3',5'-di-O-p-toluoyl-4-O-methyl-5-formylmethyl-2'-deoxyuridine was accomplishied in eleven steps from gamma-butyrolactone. This aldehyde, which should facilitate the synthesis of nucleosides containing 18F. was converted to the corresponding blocked dithianyl nucleoside, and also to 5-(2,2-difluoroethyl)-substituted derivatives of 2'-deoxyuridine and 2'-deoxycytidine.