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An interventional program to improve antibiotic use.

Cynthia L Feucht1, Louis B Rice

  • 1Pharmacy Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.

The Annals of Pharmacotherapy
|April 24, 2003
PubMed
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A multidisciplinary program reduced inappropriate antibiotic use, decreasing duplicative gram-negative coverage by 26% and shortening therapy duration. This initiative improved antimicrobial stewardship and reduced healthcare costs.

Area of Science:

  • Infectious Diseases
  • Antimicrobial Stewardship
  • Health Services Research

Background:

  • Inappropriate antimicrobial use drives resistance and increases healthcare expenditures.
  • Specific agents like vancomycin and fluoroquinolones are often overused.
  • Need for optimized prescribing practices to combat resistance and manage costs.

Purpose of the Study:

  • To implement a program aligning vancomycin and fluoroquinolone prescribing with guidelines.
  • To reduce inappropriate use and duration of these key antimicrobial agents.
  • To decrease unnecessary duplicative gram-negative coverage.

Main Methods:

  • Prospective interventional program with guideline dissemination and physician education.
  • Monthly conferences on antimicrobial resistance and hospital practices.

Related Experiment Videos

  • Clinical pharmacist prospective review of new orders with interventions.

    • Main Results:

    • Reduced unnecessary duplicative gram-negative coverage by 26% (p < 0.001).
    • Decreased overall intravenous fluoroquinolone courses by 43%.
    • Reduced prolonged use of vancomycin and fluoroquinolones by 16-22%.

    Conclusions:

    • Physician education and pharmacist interventions improved appropriate antibiotic use.
    • The program successfully decreased inappropriate antimicrobial duration and duplicate coverage.
    • Enhanced antimicrobial stewardship benefits patient care and resource management.