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Related Experiment Videos

A new method for temporary left ventricular bypass. Preclinical appraisal.

W F Bernhard, V Poirier, C C LaFarge

    The Journal of Thoracic and Cardiovascular Surgery
    |November 1, 1975
    PubMed
    Summary

    A new left ventricular assist pump offers hope for surgical patients with severe heart failure. This device provides temporary circulatory support, potentially enabling recovery in cases previously deemed unsalvageable.

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    Area of Science:

    • Cardiovascular Surgery
    • Biomedical Engineering
    • Mechanical Circulatory Support

    Background:

    • Patients unable to wean from cardiopulmonary bypass or with balloon-dependent left ventricular failure face dire prognoses.
    • Potentially reversible ventricular dysfunction offers a window for recovery with effective temporary circulatory support.

    Purpose of the Study:

    • To develop and evaluate a novel pneumatically actuated left ventricular assist pump for temporary circulatory support.
    • To assess the feasibility of the device for potential human investigation.

    Main Methods:

    • A flexible polyurethane pumping chamber device was connected to the left ventricular apex and descending thoracic aorta in 20 calves.
    • The device was implanted via midline sternotomy in a series of autopsies as a prelude to human trials.

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    Main Results:

    • All 20 animals survived the 14 to 30-day pumping interval.
    • Seven animals underwent successful device removal.
    • Autopsy implantations demonstrated feasibility for human application.

    Conclusions:

    • The developed left ventricular assist pump shows promise as a temporary circulatory support system.
    • The device's design and implantation methods are suitable for further investigation in human patients.
    • This technology may offer a life-saving option for surgical patients with severe, potentially reversible, left ventricular failure.