Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iron in neurodegenerative disorders.

D. Berg1, G. Becker, P. Riederer

  • 1Department of Neurology, Bayerische Julius-Maximilians-Universi.at Wdot;urzburg.

Neurotoxicity Research
|April 24, 2003
PubMed
Summary

Iron accumulation in the brain contributes to neurodegenerative diseases by increasing toxic radicals and protein aggregation. This review explores brain iron regulation and its role in diseases with genetic iron overload.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Bisphenol S-Induced Neurobehavioral Impairment Is Characterized by c-Jun Activation and Distinct Dysregulation of Nrf2 and BDNF in the Zebrafish Brain.

Neurotoxicity research·2026
Same journal

Biological Effects of High-Frequency Electromagnetic Fields on CNS Function and Neuroimmune Responses: A Systematic Review of In Vitro and In Vivo Experimental Studies.

Neurotoxicity research·2026
Same journal

Silymarin Reverses Seizure-Precipitating Effects of Alcohol and Associated Psychiatric Comorbidities, and Neurotoxicity in Pentylenetetrazol Pre-Kindled Mice.

Neurotoxicity research·2026
Same journal

EGF and GHRP6 Co-Administration Attenuates Cognitive Decline in Preclinical Models: Behavioral and Molecular Evidences.

Neurotoxicity research·2026
Same journal

In vivo Administration of Atorvastatin Does Not Impair Mitochondrial Function or Cellular Viability in the Prefrontal Cortex of Mice.

Neurotoxicity research·2026
Same journal

Prolonged In Vitro Exposure to Methylmalonic Acid Induces Inflammation, Glutamate Metabolism Disruption, and Alters Functional Gene Expression in C6 Astroglial Cells.

Neurotoxicity research·2026

Area of Science:

  • Neurobiology
  • Biochemistry
  • Pathology

Background:

  • Iron plays a critical role in the brain, but its dysregulation is linked to neurodegeneration.
  • Iron overload can enhance the production of toxic reactive oxygen species and promote protein aggregation, key factors in neurodegenerative disease pathogenesis.
  • The specific mechanisms driving iron accumulation in distinct brain regions affected by neurodegenerative diseases remain unclear.

Purpose of the Study:

  • To review the current understanding of iron regulation within the brain.
  • To define the existing knowledge regarding the involvement of iron metabolism in neurodegenerative diseases.
  • To focus on neurodegenerative conditions characterized by genetically determined iron accumulation in the brain.

Main Methods:

  • Literature review of molecular and biochemical studies.
  • Synthesis of current research on brain iron metabolism.
  • Analysis of the link between iron metabolism and specific neurodegenerative diseases.

Main Results:

  • Iron's capacity to generate toxic radicals and induce protein aggregation implicates it in neurodegeneration.
  • Impaired brain iron metabolism has significant consequences for neuronal health.
  • Genetically determined iron accumulation is a feature of certain neurodegenerative disorders.

Conclusions:

  • Iron dysregulation is a significant factor in the pathogenesis of various neurodegenerative diseases.
  • Understanding brain iron metabolism is crucial for elucidating disease mechanisms.
  • Further research into genetically determined iron accumulation disorders is warranted.

Related Experiment Videos