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Burkholderia is highly resistant to human Beta-defensin 3
Hany Sahly1, Sabine Schubert, Jürgen Harder
1Department of Medical Microbiology, Clinical Research Unit, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. sahly@medmicrobio.unikiel.de
Antimicrobial Agents and Chemotherapy
|April 24, 2003
Abstract:
The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC], =50 micro g/ml), except for Burkholderia cepacia, for all 23 tested strains of which MBCs were >100 micro g/ml.