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Lack of association between B19 or V9 erythrovirus infection and ANCA-positive vasculitides: a case-control study
1Department of Internal Medicine, Hôpital Avicenne, Université Paris-Nord, Unité de Recherche Clinique et Thérapeutique (EA 3409), Bobigny, France.
Objectives:
To examine the potential association of human B19 or V9 erythrovirus infection and onset of ANCA-positive vasculitides.
Methods:
We tested the sera of 13 adults with newly diagnosed ANCA-positive vasculitides. Each was age- and sex-matched to three sera obtained from healthy controls. All samples were tested for B19- and V9-specific immunoglobulin (Ig) G and IgM antibodies (Ab) (third-generation ELISA), and B19 or V9 DNA was sought with the polymerase chain reaction. Statistical analysis was performed by conditional logistic regression.
Results:
Patient diagnoses comprised six cases of Wegener's granulomatosis, six of microscopic polyangiitis and one of Churg-Strauss syndrome. IgG Ab to B19 were detected equally in patient and control sera (77 and 79% respectively) (odds ratio=0.84, P=0.84). All 13 cases and 39 controls were negative for IgM Ab and viral DNA.
Conclusion:
These results suggest that neither acute nor chronic B19 or V9 infection is an aetiological factor in ANCA-associated vasculitides.