Related Experiment Video
Updated: Aug 9, 2026

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
[Antibiotics and kidney]
S. Nardiello1, F. Catapano, B. Galanti
1Istituto di Malattie Infettive e Cattedra di Nefrologia, Seconda Universita degli Studi di Napoli, Italy.
Abstract:
Renal excretion is the most important route of elimination for the majority of antibiotics, and some antibiotics may cause renal injury by direct and/or immunologic mechanisms. These conditions determine a dose relationship between antibiotic therapy and renal function. In this review we report some practical guidelines for the correct administration of antibiotics in patients with decreased renal function. Currently used antibiotics that are most frequently associated to nephrotoxicity are also examined, and for each of them the incidence and degree of renal damage, pathogenic mechanisms and preventive measures are reported. This review emphasizes the need for a careful assessment of renal function in patients with acute and chronic infections undergoing antibiotic therapy.
Related Concept Videos
Drug Elimination by Renal Route: Tubular Secretion
Acute Pyelonephritis II: Diagnostic Studies and Management
Kidney Transplant II: Surgical Procedure
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury V: Interprofessional Care
Urine Studies II: Urine Culture and Sensitivity Test

