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Sedation with midazolam for voiding cystourethrography in children: a randomised double-blind study
Eira Stokland1, Svenerik Andréasson, Bo Jacobsson
1Department of Paediatric Radiology and Clinical Physiology, The Queen Silvia Children's Hospital, 41685 Gothenburg, Sweden. eira.stokland@vgregion.se
Pediatric Radiology
|April 24, 2003
Summary
Midazolam sedation reduces distress during voiding cystourethrography (VCUG) in children. This study found midazolam safe and effective for pediatric VCUG, with no negative impact on diagnostic outcomes.
Area of Science:
- Pediatric imaging and procedural sedation.
Background:
- Sedation aids diagnostic procedures like voiding cystourethrography (VCUG) in children.
- The impact of sedation on VCUG outcomes requires further evaluation.
Purpose of the Study:
- To compare midazolam and placebo for discomfort during pediatric VCUG.
- To assess if midazolam sedation affects VCUG examination results.
Main Methods:
- Prospective, randomized, double-blind study of 95 children undergoing VCUG.
- Comparison of midazolam versus placebo for child/parent experience and examination outcomes.
Main Results:
- Midazolam significantly reduced distress during VCUG compared to placebo (P<0.001).
- No significant difference in voiding, reflux, or bladder emptying between midazolam and placebo groups.
- 46/48 midazolam-sedated children voided vs. 38/47 placebo.
Conclusions:
- Midazolam is a suitable sedative for pediatric VCUG when needed.
- Sedation with midazolam does not negatively impact VCUG diagnostic outcomes.