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Recurrent plunging ranula treated with OK-432.

Jeong-Su Woo1, Soon Jae Hwang, Heung-Man Lee

  • 1Department of Otorhinolaryngology and Head and Neck Surgery, Communication Disorder Institute of the Medical Science Research Center, Korea University College of Medicine, Seoul, Korea.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|April 24, 2003
PubMed
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Sclerotherapy using OK-432 effectively treated a recurrent plunging ranula in a patient previously treated with surgery. This minimally invasive approach led to complete cyst disappearance and no recurrence after one year.

Area of Science:

  • Oral and Maxillofacial Surgery
  • Surgical Oncology
  • Regenerative Medicine

Background:

  • Recurrent plunging ranula presents a significant challenge in oral and maxillofacial surgery.
  • Previous surgical interventions for ranula can lead to recurrence and complications.

Observation:

  • A 36-year-old male presented with a recurrent plunging ranula, a cyst originating from the submandibular gland and floor of the mouth.
  • The patient had a history of two prior surgical excisions for the same condition.

Findings:

  • Sclerotherapy with OK-432 (Picibanil) was administered under fluoroscopic guidance.
  • Two sessions of OK-432 injection, with 3-week intervals, resulted in complete resolution of the cystic mass.
  • No recurrence was observed during a 1-year follow-up period.

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Implications:

  • OK-432 sclerotherapy offers a promising, minimally invasive alternative for managing recurrent plunging ranulas.
  • This treatment modality may reduce the need for further extensive surgical procedures.
  • Further research into OK-432 sclerotherapy for ranulas could establish it as a standard treatment option.