Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vaginal immunity in the HSV-2 mouse model.

Margaret B Parr1, Earl L Parr

  • 1Department of Anatomy, Southern Illinois University, Carbondale, Illinois 62901-6523, USA. mparr@siumed.edu

International Reviews of Immunology
|April 25, 2003
PubMed
Summary

Understanding female genital tract immunity to herpes simplex virus type 2 (HSV-2) is crucial for vaccine development. Research in mouse models highlights the importance of both antibody and T cell responses for protection against this sexually transmitted infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravaginal administration of herpes simplex virus type 2 to mice leads to infection of several neural and extraneural sites.

Journal of neurovirology·2003
Same author

Prospects for an AIDS vaccine.

Science (New York, N.Y.)·2002
See all related articles

Area of Science:

  • Immunology
  • Virology
  • Reproductive Health

Background:

  • Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted pathogen.
  • Effective vaccines against genital HSV-2 infections are lacking.
  • Understanding protective immune mechanisms in the female reproductive tract is essential for vaccine design.

Purpose of the Study:

  • To review recent studies on mucosal immunity to HSV-2 in the female genital tract.
  • To explore the role of immune responses in protecting against HSV-2 infection.
  • To inform the development of HSV-2 vaccines for women.

Main Methods:

  • Utilized a progestin-treated adult mouse model.
  • Investigated immune responses in the vaginal mucosa.
  • Focused on humoral and T cell immunity.

Related Experiment Videos

Main Results:

  • Evidence suggests a significant role for both humoral (antibody-mediated) immunity.
  • T cell-mediated immunity also plays a major part in protection.
  • The mouse model provides insights into protective immune mechanisms.

Conclusions:

  • Both humoral and T cell immunity are critical for mucosal defense against HSV-2.
  • Further research in this area can guide the development of effective genital HSV-2 vaccines.
  • Understanding these immune mechanisms is key to preventing HSV-2 transmission.