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Limonoids from Citrus reticulata.

Ashraf T Khalil1, Galal T Maatooq, Khalid A El Sayed

  • 1Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. ashraf-khalil2001@yahoo.com

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|April 25, 2003
PubMed
Summary

Researchers discovered a new limonoid derivative, isolimonexic acid methyl ether, from Citrus reticulata seeds. This compound showed marginal antimalarial activity in initial studies.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Medicinal Chemistry

Background:

  • Citrus reticulata (tangerine) seeds are a potential source of bioactive compounds.
  • Limonoids are a class of terpenoids found in citrus plants with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new limonoid derivatives from Citrus reticulata seeds.
  • To evaluate the antimalarial potential of the isolated compounds.

Main Methods:

  • Extraction and isolation of compounds from Citrus reticulata seeds.
  • Structure elucidation using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
  • In vitro assessment of antimalarial activity.

Main Results:

  • Isolation of a new limonoid derivative, isolimonexic acid methyl ether.
  • Identification of known limonoids: limonin, deacetylnomilin, obacunone, and ichangin.
  • Isolimonexic acid methyl ether exhibited marginal antimalarial activity.

Conclusions:

  • Citrus reticulata seeds are a rich source of diverse limonoids.
  • Isolimonexic acid methyl ether represents a novel limonoid structure.
  • Further investigation is warranted to explore the therapeutic potential of this compound.

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