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Altered spontaneous discharge rate and pattern of basal ganglia output neurons in the circling (ci2) rat mutant.

M Fedrowitz1, S Lindemann, W Löscher

  • 1Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.

Neuroscience
|April 25, 2003
PubMed
Summary

Circling rats (ci2/ci2) exhibit abnormal basal ganglia output. Increased substantia nigra pars reticulata (SNr) neuron activity in these mutants likely contributes to their complex motor deficits.

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Area of Science:

  • Neuroscience
  • Genetics
  • Animal Models

Background:

  • The circling rat (ci2/ci2) is an autosomal recessive mutant exhibiting rotational behavior, hyperactivity, ataxia, and deafness.
  • Previous studies identified lower striatal dopamine levels ipsilateral to the circling direction in ci2 rats.

Purpose of the Study:

  • To investigate functional consequences of striatal dopamine imbalance in basal ganglia structures.
  • To record neuronal activity in the striatum and substantia nigra pars reticulata (SNr) of ci2 rats.

Main Methods:

  • Recorded spontaneous extracellular single unit activity of GABAergic neurons bilaterally in anesthetized ci2 rats, heterozygous littermates (ci2/+), and background strain rats (LEW/Ztm).
  • Analyzed discharge rate and firing patterns in the striatum and SNr.

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Main Results:

  • No significant hemispheric imbalances or intergroup differences in striatal neuronal activity were observed.
  • A significant increase in spontaneous discharge rate of SNr neurons was found bilaterally in ci2 rats.
  • Ci2 mutants displayed a significant shift towards rhythmic burst-like firing in SNr neurons.

Conclusions:

  • The findings substantiate altered basal ganglia function in ci2 rats.
  • Abnormal basal ganglia output, specifically from the SNr, is likely a key contributor to the complex behavioral disturbances observed in ci2 mutants.