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Note on the measurement of flowability according to the European Pharmacopoeia
Andrea Schüssele1, Annette Bauer-Brandl
1Department of Pharmaceutcis and Biopharmaceutics, Institute of Pharmacy, University of Tromsø, Universitetsveien 57, N-9037 Tromsø, Norway.
Abstract:
Flowabilities of six commercially available, direct compression excipients, Emcompress, Fujicalin, Starch 1500, Avicel PH-102, Tablettose 80, and Tablettose 100 were examined according to the technical procedure described in the current European Pharmacopoeia, and with a Sotax Flow Tester. Results revealed unfavourable properties for Fujicalin compared to other substances. Fujicalin, however, appeared macroscopically to be of extremely pronounced free-flowing properties. This contradiction was studied in more detail, proposing to express powder flow in terms of volume per time unit rather than mass per time unit (volume-flowability).
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