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Interrupted aortic arch in infancy.

R L Collins-Nakai, M Dick, L Parisi-Buckley

    The Journal of Pediatrics
    |June 1, 1976
    PubMed
    Summary
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    Interrupted aortic arch in infants is a severe condition with high mortality. Early surgical repair using deep hypothermia and circulatory arrest offers a promising treatment approach.

    Area of Science:

    • Pediatric Cardiology
    • Congenital Heart Defects
    • Surgical Innovation

    Background:

    • Interrupted aortic arch (IAA) is a critical congenital heart defect.
    • Infants with IAA often present with complex associated cardiac abnormalities.
    • Historical data indicates high mortality rates for IAA without effective treatment.

    Purpose of the Study:

    • To review historical outcomes of infants with interrupted aortic arch.
    • To evaluate the efficacy of surgical interventions for IAA.
    • To propose an improved treatment strategy for IAA.

    Main Methods:

    • Retrospective review of 30 infants diagnosed with interrupted aortic arch.
    • Analysis of associated cardiac defects and surgical interventions.

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  • Comparison of mortality rates between surgical and non-surgical management.

    • Main Results:

    • High hospital mortality (76%) observed in surgically treated infants (21 patients).
    • Eight out of nine non-surgically treated infants died within days.
    • Associated defects included ventricular septal defect, patent ductus arteriosus, and outflow tract obstruction.

    Conclusions:

    • Traditional surgical approaches for IAA had poor outcomes.
    • One-stage primary repair utilizing deep hypothermia and circulatory arrest is proposed.
    • This advanced surgical technique aims to improve survival rates for IAA infants.