Related Experiment Video
Updated: Aug 19, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
[Immunohistochemical research on breast cancer cell proliferation and hormonal receptor status with special emphasis
R Ohlinger1, S M Steffen, F Oellig
1Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Ernst-Moritz-Universität Greifswald.
Abstract:
Breast cancer is the most frequent gynecological tumor. The HER-2/neu oncogene may play a role in the prognosis and management of patients with breast cancer. In a retrospective study on 100 patients, we correlated the expression of this oncogene with the classic clinical and pathological factors. 32 % of patients exhibited overexpression of HER-2/neu. There was no significant correlation with classic parameters. This finding could indicate that HER-2/neu expression is a new independent prognostic factor. Prospective studies correlating HER-2/neu overexpression with prognosis might provide additional data.

