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Updated: Sep 26, 2026

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
Published on: February 22, 2019
[Mechanisms of activation of pathogenic bacteria in the host organism]
Iu M Romanova1, R Kh Boshnakov, T V Baskakova
1Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Abstract:
A minireview of the data of literature on the interaction of bacteria with cytokins and the stimulation of the growth of pathogenic bacteria by some cytokins is presented. The addition of tumor necrosis factor-alpha into the culture medium has been shown to stimulate the growth of Salmonella virulent and avirulent strains 4-fold and 2-fold respectively. This cytokin has also been shown to produce a stimulating effect on the process of the in vitro and in vivo recultivation of noncultivating forms of virulent and avirulent strains.
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