[Research on nitric oxide, oxidative and lipid peroxidative parameters in blood of diabetic patients]

Plasma nitric oxide(P-NO), vitamin C(P-VC), vitamin E(P-VE), beta-carotene (P-beta-CAR), lipoperoxides (P-LPO) contents, the activities of erythrocyte superoxide dismutase(E-SOD), catalase(E-CAT), glutathione peroxidase (E-GSH-Px) and lipoperoxides (E-LPO) in 114 diabetic patients and 100 healthy subjects were measured. Compared with the control group, the average contents of P-NO, P-LPO and E-LPO of patient, were higher (P < 0.01), while P-VC, P-VE, P-beta-CAR contents and E-SOD, E-CAT and E-GSH-Px activities were lower (P < 0.01). With the advance of disease courses, the P-NO, P-LPO and E-LPO contents of diabetic patients increased, while P-VC, P-VE, P-beta-CAR, E-SOD, E-CAT and E-GSH-Px decreased(P < 0.01). The stepwise regression showed that the correlation between disease courses and P-NO, P-VC, E-SOD, E-GSH-Px and E-LPO values was significant. The metabolism of nitric oxide in diabetic patients was abnormal, and the antioxidation, antiperoxidation and antilipoperoxidation were depressed.