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[Common variable immunodeficiency--advances in diagnosis, pathogenesis and treatment]
1Katedra i Zakład Immunologii Klinicznej, Uniwersytetu Medycznego w Łodzi. rafal.pawliczak@csk.am.lodz.pl
Summary
Common variable immunodeficiency (CVI) is a frequent congenital immune disorder with mixed T and B-cell dysfunction. This review details CVI
Area of Science:
- Immunology
- Genetics
Context:
- Common variable immunodeficiency (CVI) is a primary immunodeficiency with varied clinical presentations.
- Despite extensive research, the pathogenesis of CVI remains incompletely understood.
Purpose:
- To provide a comprehensive overview of Common Variable Immunodeficiency (CVI).
- To discuss the definition, clinical manifestations, diagnosis, and management of CVI.
- To review current literature on CVI pathogenesis and Good's syndrome.
Summary:
- CVI is a common, congenital immunodeficiency often inherited in an autosomal recessive pattern.
- Pathogenesis involves T and B-cell functional disorders, leading to diverse symptoms.
- This paper covers clinical aspects, diagnosis, therapy, and modern insights into CVI.
Impact:
- Enhances understanding of CVI, aiding clinical diagnosis and management.
- Highlights the need for further research into CVI pathogenesis.
- Provides a resource for clinicians and researchers on CVI and Good's syndrome.