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[Viral hepatitis C in patients with renal disease]

Ana M Contreras1

  • 1Departamento de Investigación y Nefrología, Centro Médico Nacional de Occidente, 44280 Guadalajara, Jal. acontreras53@hotmail.com

Revista De Gastroenterologia De Mexico
|April 26, 2003
PubMed

Insights

Hepatitis C virus (HCV) infection is common in chronic renal failure patients. While not impacting survival, cirrhosis from HCV prevents kidney transplants.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Context:

  • Hepatitis C virus (HCV) infection is a frequent complication in patients undergoing chronic dialysis, with prevalence ranging from 8% to 65%.
  • Viral hepatitis is a leading cause of morbidity and mortality in renal transplant recipients, with HCV prevalence varying from 4% to 38% globally.
  • HCV infection often precedes transplantation but can also occur during the procedure via infected donor organs.

Purpose:

  • To review the prevalence, implications, and management of Hepatitis C virus infection in patients with chronic renal failure and undergoing renal transplantation.
  • To highlight the impact of chronic HCV infection on patient and graft survival, and its contraindication for kidney transplantation.

Summary:

  • HCV infection is highly prevalent in chronic renal failure patients on dialysis.
  • Interferon is the recommended antiviral treatment for dialysis-dependent patients with chronic hepatitis C.
  • Chronic HCV infection does not significantly affect patient or organ survival, but cirrhosis is a contraindication for renal transplantation.
  • Liver failure causes 8-28% of deaths in HCV-infected renal transplant recipients.

Impact:

  • Understanding HCV prevalence and management is crucial for improving outcomes in renal failure patients.
  • Identifying cirrhosis as a contraindication for renal transplant helps in patient selection and management.
  • This review informs clinical practice regarding vaccination, antiviral therapy, and transplant eligibility for HCV-infected renal patients.

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