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[Extrahepatic symptoms of HCV infection]
1Departamento de Gastroenterología, Hospital Central Militar, Blvd. Manuel Avila Camacho S/N, Col. Lomas de Sotelo, Deleg. Miguel Hidalgo 11200 México, D.F. jaguilar@intelimedic.com
Insights
Hepatitis C virus (HCV) infection is linked to numerous extrahepatic manifestations, including skin, joint, and kidney issues. This study explores the prevalence and associations of these diverse clinical and biologic conditions in HCV patients.
Area of Science:
- Hepatology
- Virology
- Immunology
Context:
- Hepatitis C virus (HCV) infection is associated with a wide range of systemic complications beyond the liver.
- Extrahepatic manifestations (EHMs) significantly impact patient morbidity and quality of life.
Purpose:
- To determine the prevalence of various clinical and biologic extrahepatic manifestations in patients with Hepatitis C virus infection.
- To identify potential associations between these EHMs and specific patient characteristics or liver disease factors.
Summary:
- The study reviewed dermatologic, rheumatologic, neurologic, and nephrologic manifestations, alongside diabetes, hypertension, autoantibodies, and cryoglobulins in HCV patients.
- Analysis focused on identifying correlations between these EHMs and liver histology, as well as among the manifestations themselves.
Impact:
- Provides a comprehensive overview of the spectrum of EHMs in HCV infection.
- Aims to improve understanding of HCV pathogenesis and guide clinical management strategies for associated systemic conditions.
Abstract:
Numerous extrahepatic manifestations have been reported in association with hepatitis c virus (HCV) infection, including mixed cryoglobulinemia, porphyria cutanea tarda, membranoproliferative glomerulonephritis, and a high prevalence of autoantibodies. The aims of the present paper is to present the prevalence of clinical and biologic extrahepatic manifestation and to identify associations between these manifestation. The prevalence of dermatologic, rheumatologic, neurological, and nephrologic manifestations, diabetes, arterial hypertension, autoantibodies, and cryoglobulins and liver histologic factors associated with the presence of extrahepatic manifestations reported in the literature.